The Use and Abuse of Corticosteroids
Corticosteroids sometimes referred to simply as ‘steroids’,
form a large groups of drugs with a common chemical structure. They possess a diverse range of
pharmacological and clinical actions.
Steroids with muscle building potential called “anabolic steroids” are
sometimes used for wasting diseases, and abused by athletes or other sports
persons. We for the present, are
primarily concerned here with corticosteroids used as medicine for different
diseases.
Corticosteroids are normally occurring hormones in the
body. There are three types of steroids
– mineralo-corticoids, glucocorticoids and the gonadocorticoids (sex
hormones). The gonadocorticoids are
produced by the gonads (testes in males and ovaries in females), while the
mineralo- and glucocorticoids are produced by adrenal glands located in the
abdomen, resting over the two kidneys – therefore they are also called
supra-renal glands. Their production and
release is governed by the pituitary gland located in the brain.
Corticosteroids, which are used as medicine, are chemically
synthesized. There is a large number of
synthetic corticosteroids manufactured for use as drugs. While individual
products have one or the other advantage, the primary actions are common to all
the brands. The mineralo-corticoids
influence metabolism of ‘minerals’ i.e. sodium and potassium, while the
gluco-corticoids are important in glucose and fat metabolism.
There are extensive indications for the medical use of
corticosteroids. Their use in adrenal
deficiency is primarily for replacement therapy. More commonly, they are used for suppression
of immune activity or to control inflammation in a large number of
immunological and inflammatory diseases.
In respiratory conditions, they are used in different stages of asthma
and other allergies, chronic obstructive lung diseases, sarcoidosis, certain
type of interstitial lung diseases, and pulmonary vasculitic disorders. They are also used in many other medical
illnesses – rheumatoid arthritis, polyarteritis nodosa, systemic vasculitides,
skin allergies, urticaria, eczema, eye allergies, allergic rhinitis and a
number of other common or uncommon diseases.
Steroids are lifesaving in severe anaphylactic shock, acute severe
asthma, transplant rejections and diffuse lung haemorrhage (etc.).
There is no other choice when the medical indication for
this use is clear and strong. What is
more worrying is their irrational and prolonged use, frequently without the
knowledge of the patient. There is no
monitoring of side effects or attempts at their prevention. It is common in this country for some medical
practitioners to use small doses of corticosteroids even when there is no
medical indication, to provide ‘magical relief’ to the patient to earn
credit. This is an abuse which must be
avoided at all costs.
Corticosteroids, when used for longer periods in an
un-regulated fashion, can lead to occurrence of complications such as salt and
water accumulation which manifests with swelling of face and feet, hypertension,
glucose intolerance or even frank diabetes,.
They also cause osteoporosis and bone- loss predisposing to spontaneous
fractures of bones and complications such as collapse of vertebrae or necrosis
of hip-joint bones. Fat redistribution results in thinning of limbs (arms and
legs), accumulation of fat over the neck and the upper-back. Muscle wasting, abnormal
striae over the body (arms and abdomen), acne and petechiae can also
occur. The symptoms of acidity and
gastro-esophageal reflux (retrosternal burning, dyspepsia) are common. There is also an increased frequency of
infection, including tuberculosis in such patients.
It is important to give supplemental calcium and vitamin D
to most of the patients receiving corticosteroids. Regular monitoring is most important which should
be done for blood pressure, blood sugar levels, weight gain/ loss, serum
calcium and vitamin D levels.
In summary, the corticosteroids use constitutes a double
edged sword. The use, when medically
indicated, works like a wonder. Most importantly, the long-term effects need to
be carefully assessed. The wisdom lies in the discretion to decide the
indication. This should be done on the
basis of available medical evidence, and not on the whims and fancies of an
individual practitioner.
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